Ishusho igezweho yahishuye amabanga y'igenzura ry'urujya n'uruza rw'ibinyabutabire

Kimwe n'uko abategura imijyi batunganya neza urujya n'uruza rw'ibinyabiziga mu mujyi rwagati, uturemangingo tugenzura neza urujya n'uruza rw'uturemangingo mu mijyi. Dukora nk'abarinzi b'ingoboka za kirimbuzi, uturemangingo tw'uturemangingo twa kirimbuzi (NPCs) dushyirwa mu ruhu rw'ingufu za kirimbuzi dukomeza kugenzura neza ubu bucuruzi bw'uturemangingo. Ubushakashatsi butangaje bwakozwe na Texas A&M Health burimo kugaragaza uburyo iyi gahunda ikora neza, bushobora gutanga ibitekerezo bishya ku ndwara zo kwangirika kw'imitsi n'iterambere rya kanseri.

Gukurikirana inzira za molekile mu buryo bushya

Itsinda ry’ubushakashatsi rya Dr. Siegfried Musser muri Texas A&M College of Medicine ryatangije ubushakashatsi ku buryo molekile zinjira vuba kandi zidafite impanuka mu buryo bunyura mu rusobe rw’ingirabuzimafatizo ebyiri. Igitabo cyabo cy’ingenzi cya Nature kivuga ku byavumbuwe n’ikoranabuhanga rya MINFLUX - uburyo bugezweho bwo gufata amashusho bushobora gufata imiterere ya molekile ya 3D ibaho mu masegonda make ku gipimo kingana n’inshuro 100.000 z’ubugari bw’umusatsi w’umuntu. Bitandukanye n’ibyo batekerezaga mbere ku nzira zitandukanye, ubushakashatsi bwabo bwerekana ko inzira zinjira n’izoherezwa mu mahanga za kirimbuzi zihurirana mu miterere ya NPC.

Ibitangaza bigamije guhangana n'ibintu bihari mu bushakashatsi

Ibyo itsinda ryabonye byagaragaje imiterere y’urujya n’uruza rw’ibintu mu buryo butunguranye: molekile zigenda mu cyerekezo cy’ibice bibiri zinyuze mu miyoboro ifunganye, zizengurukana aho gukurikira inzira zabigenewe. Igitangaje ni uko utu duce twibanda hafi y’inkuta z’imiyoboro, bigatuma agace ko hagati katagira ikintu kigaragara, mu gihe iterambere ryatwo rigabanuka cyane - inshuro zigera ku 1.000 ugereranyije n’ingendo zidateje akaga - bitewe n’imiyoboro ya poroteyine ibangamira ikora ibidukikije bivanze n’amazi.

Musser asobanura ibi nk' "ahantu hagoye cyane ho mu muhanda - inzira ebyiri zinyura mu nzira nto." Yemera ati: "Ibyo twabonye bigaragaza uburyo butunguranye bwo guhuza ibintu, bigaragaza uburyo bugoye kurusha uko ibitekerezo byacu bya mbere byabigaragazaga."

Gukora neza nubwo hari inzitizi

Igitangaje ni uko sisitemu zo gutwara abantu za NPC zigaragaza imikorere itangaje nubwo hari izi mbogamizi. Musser aratekereza ati: “Ubwinshi bw’ibintu bya NPC bushobora gukumira imikorere irenze ubushobozi bw’indege, bikagabanya ingaruka zo kubangamirana no kuziba.” Iyi miterere y’ibintu isa nkaho ibuza ihuriro ry’ibintu, hano'verisiyo yanditswe bundi bushya ifite imyandikire itandukanye, imiterere, n'ibice by'ibika mu gihe ikomeza gusobanura umwimerere:

Urujya n'uruza rw'ibintu mu buryo bwa molekile rwagiye mu nzira inyuramo: NPC zahishuye inzira zihishe

Aho kunyura muri NPC'Mu gice cyo hagati cy'umuyoboro, molekile zisa nkaho zinyura muri imwe mu miyoboro umunani yihariye yo gutwara ibintu, buri imwe ifatanye n'imiterere isa n'iyavuga ku mwenge'impeta y'inyuma. Iyi gahunda y'ahantu igaragaza uburyo bw'ibanze bw'inyubako bufasha mu kugenzura urujya n'uruza rwa molekile.

Musser arasobanura,"Mu gihe utwenge tw’imisemburo y’umusemburo tuzwiho kuba dufite'imashini yo hagati,'Imiterere yayo nyayo iracyari amayobera. Mu turemangingo tw'abantu, iyi miterere ifite'byagaragaye, ariko gushyira mu byiciro imikorere birashoboka—n'umuyoboro'ikigo gishobora kuba inzira nyamukuru yo kohereza mRNA mu mahanga."

Isano ry'indwara n'imbogamizi mu buvuzi

Ikosa muri NPC—inzira y'ingenzi ya telefoni zigendanwa—byafitanye isano n'indwara zikomeye zo mu bwonko, harimo na ALS (Lou Gehrig)'indwara ya Alzheimer),'s, na Huntington'indwara. Byongeye kandi, ibikorwa byo gucuruza NPC bifitanye isano no kwiyongera kwa kanseri. Nubwo kwibanda ku turere twihariye tw’imyobo bishobora gufasha mu gukuraho inzitizi cyangwa kugabanya gutwara ibintu byinshi, Musser amenyesha ko guhindura imikorere ya NPC bigira ingaruka mbi, bitewe n’uruhare rwayo rw’ibanze mu kubaho kw’uturemangingo.

"Tugomba gutandukanya inenge zijyanye n'ubwikorezi n'ibibazo bifitanye isano na NPC'guteranya cyangwa gusenya,"aragira ati."Nubwo hari isano nyinshi hagati y’indwara zishobora kuba ziri muri icyo cyiciro cya nyuma, hari ibidasanzwe—nka c9orf72 gene mutations muri ALS, birema aggregates zifunga umwobo ku buryo bufatika."

Amabwiriza y'ejo hazaza: Gushushanya inzira z'imizigo n'ishusho y'uturemangingo tuzima

Musser n'umufatanyabikorwa Dr. Abhishek Sau, bakomoka muri Texas A&M'Laboratwari ya Microscopy Ihuriro, irateganya gukora iperereza niba ubwoko butandukanye bw'imizigo—nk'uduce duto twa ribosomal na mRNA—bakurikiza inzira zidasanzwe cyangwa bagahurira ku nzira zihuriweho. Umurimo wabo ukomeje n'abafatanyabikorwa b'Abadage (EMBL na Abberior Instruments) ushobora kandi guhindura MINFLUX kugira ngo ikore amashusho y'ingirabuzimafatizo mu buryo bw'igihe nyacyo, bigatanga ibitekerezo bidasanzwe ku mikorere y'ubwikorezi bwa kirimbuzi.

Ubu bushakashatsi bushyigikiwe n'inkunga ya NIH, buvugurura uburyo twumva ibijyanye n'itumanaho rya telefoni zigendanwa, bwerekana uburyo NPC zibungabunga umutekano mu mujyi munini w'itsinda ry'abantu bafite ubumuga bwo mu mutwe.