Kongera uburyo bwo kwita ku barwayi hakoreshejwe uburyo bwo kugabanya ubukana bw'indwara zanduzanya (AI-Based Attenuation Correction) mu gushushanya PET

Ubushakashatsi bushya bufite umutwe ugira uti “Gukoresha Pix-2-Pix GAN mu gukosora ihungabana ry’umubiri wose rishingiye ku kwiga cyane PSMA PET/CT” buherutse gusohoka mu gitabo cya Oncotarget Volume 15 ku ya 7 Gicurasi 2024.

Indwara y’imirasire ituruka ku bushakashatsi bwa PET/CT bukurikiranye mu gukurikirana abarwayi ba kanseri ni ikibazo gikomeye. Muri ubu bushakashatsi buherutse gukorwa, itsinda ry’abashakashatsi barimo Kevin C. Ma, Esther Mena, Liza Lindenberg, Nathan S. Lay, Phillip Eclarinal, Deborah E. Citrin, Peter A. Pinto, Bradford J. Wood, William L. Dahut, James L. Gulley, Ravi A. Madan, Peter L. Choyke, Ismail Baris Turkbey, na Stephanie A. Harmon bo mu Kigo cy’Igihugu gishinzwe kurwanya kanseri mu Kigo cy’Igihugu cy’Ubuzima bashyize ahagaragara igikoresho cy’ubwenge bw’ubukorano (AI). Iki gikoresho kigamije gukora amashusho ya PET (AC-PET) yahinduwe attenuation-corrected attenuation-corrected PET (NAC-PET) aturutse ku mashusho ya PET (NAC-PET) adakozwe attenuation-corrected non-attenuation-corrected), bishobora kugabanya gukenerwa kwa CT scan ku gipimo gito.

“Amashusho ya PET yakozwe na AI afite ubushobozi bwo kugabanya gukenera gukosora CT scans mu gihe abungabunga ibimenyetso by’imibare n’ubwiza bw’ishusho ku barwayi ba kanseri ya prostate.”

Uburyo: Uburyo bwo kwiga byimbitse bushingiye ku miterere ya 2D Pix-2-Pix generative adversarial network (GAN) bwakozwe hashingiwe ku mashusho ya AC-PET na NAC-PET. Inyigo ya 18F-DCFPyL PSMA (Prostate-specific membrane antigen) PET-CT yakorewe ku barwayi 302 barwaye kanseri ya prostate yagabanijwemo amatsinda y’amahugurwa, kwemeza, n’ibizamini (n 183, 60, na 59, uko bikurikirana). Icyitegererezo cyahuguwe hakoreshejwe ingamba ebyiri zisanzwe: Standard Uptake Value (SUV) ishingiye kuri na SUV-NYUL ishingiye kuri. Scanning horizontal performance yapimwe hakoreshejwe normalized mean square error (NMSE), mean absolute error (MAE), structural similarity index (SSIM) na peak signal-to-noise ratio (PSNR). Umuganga w’imiti ya nucleial yakoze isesengura ry’urwego rw’ibisebe ku gace k’ingenzi. Ibipimo bya SUV byapimwe hakoreshejwe intra-group correlation coefficient (ICC), repeatability coefficient (RC), na linear mixed effects models.

Ibisubizo:Mu itsinda ryigenga ry’ibizamini, igipimo cya NMSE, MAE, SSIM, na PSNR cyari 13.26%, 3.59%, 0.891, na 26.82, uko bikurikirana. ICC ya SUVmax na SUV yari 0.88 na 0.89, bigaragaza isano ikomeye hagati y’ibimenyetso by’ishusho byakozwe n’ibyakozwe na AI. Ibintu nk’aho ibisebe biherereye, ubucucike (ibice bya Hounsfield), n’uburyo ibisebe byakoreshejwe byagaragaye ko bigira ingaruka ku ikosa ryakozwe mu bipimo bya SUV (byose p < 0.05).

“AC-PET yakozwe na Pix-2-Pix GAN igaragaza ibipimo bya SUV bihuye neza n'amashusho y'umwimerere. Amashusho ya PET yakozwe na AI agaragaza ubushobozi bwo kuvura butanga icyizere mu kugabanya gukenera gupimwa kwa CT kugira ngo hakosorwe uburyo bwo kugabanya ubukana bw'ishusho mu gihe hagumaho ibimenyetso by'imibare n'ubwiza bw'ishusho.”

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