Umukozi wa MRI wikora ku giti cye (Revolutionary Self-folding Nanoscale MRI Agent) atuma amashusho ya kanseri agaragara neza

Gufata amashusho y’ubuvuzi akenshi bifasha mu gusuzuma no kuvura neza ibibyimba bya kanseri. By’umwihariko, gufotora amashusho ya magnetic resonance (MRI) bikoreshwa cyane bitewe n’uko bifite ubushobozi bwo kureba neza, cyane cyane iyo bikoreshejwe mu kugabanya isura.

Ubushakashatsi bushya bwasohotse mu kinyamakuru Advanced Science buvuga ku kintu gishya cyo gutandukanya ibice bya nanoscale gishobora gufasha mu kureba neza ibibyimba binyuze muri MRI.

Igitandukanye ni iki?itangazamakuru?

 Ibyuma bigabanya ubukana (bizwi kandi nka contrast media) ni imiti iterwa (cyangwa ijyanwa) mu ngingo z'umuntu cyangwa mu ngingo kugira ngo yongere kureba amashusho. Iyi miti iba ikomeye cyangwa iri munsi y'ingingo ziyikikije, bigatuma habaho contrast ikoreshwa mu kwerekana amashusho hakoreshejwe ibikoresho bimwe na bimwe. Urugero, imyitere ya iyode, barium sulfate, nibindi bikunze gukoreshwa mu gusuzuma X-ray. Iterwa mu mitsi y'amaraso y'umurwayi binyuze muri syringe ifite umuvuduko mwinshi.

Kuri nanoscale, molekile ziguma mu maraso igihe kirekire kandi zishobora kwinjira mu tumori dukomeye tudateye ubudahangarwa bw’umubiri bwihariye bwa kanseri. Hari ubwoko bwinshi bwa molekile bushingiye kuri nanomolecules bwakoreweho ubushakashatsi nk'abashobora gutwara CA mu tumori.

Izi nganda zigabanya ubukana bw’amaraso (NCAs) zigomba gukwirakwizwa neza hagati y’amaraso n’ingingo zikenewe kugira ngo bigabanye urusaku rw’inyuma kandi zigere ku gipimo ntarengwa cy’urusaku ku rundi (S/N). Iyo zigize ubukana bwinshi, NCA iguma mu maraso igihe kirekire, bityo ikongera ibyago byo kurwara fibrosis nyinshi bitewe no kurekura iyoni za gadolinium ziva muri iyo complex.

Ikibabaje ni uko NCA nyinshi zikoreshwa ubu zirimo ubwoko butandukanye bwa molekile. Munsi y'umubare runaka, izi micelles cyangwa aggregates zikunda kwitandukanya, kandi ingaruka z'iki gikorwa ntizisobanutse neza.

Ibi byatumye habaho ubushakashatsi ku macromolecules ya nanoscale yikora ubwayo idafite urwego rw'ingenzi rwo kwitandukanya. Izi zigizwe n'inyama z'umunyu n'igice cyo hanze gishongesha kandi kigabanya urujya n'uruza rw'ibinyabutabire bishongesha mu buryo bunyuramo. Ibi bishobora kugira ingaruka ku bipimo byo kuruhuka kwa molekile n'indi mirimo ishobora guhindurwa kugira ngo hongerwe uburyo bwo gutanga imiti n'imiterere yayo mu mubiri.

Ubusanzwe, imashini itera impuzankano (contrast media) ishyirwa mu mubiri w'umurwayi ikoresheje inshinge zitera impuzankano zikoresha umuvuduko mwinshi.LnkMed, uruganda rw’inzobere rwibanda ku bushakashatsi no guteza imbere injecti zikoresha ikoranabuhanga ritandukanye hamwe n’ibikoresho bikoreshwa, rwagurishijeCT, MRI, naDSAinshinge mu gihugu no mu mahanga kandi zemewe n'isoko mu bihugu byinshi. Uruganda rwacu rushobora gutanga ubufasha bwoseibikoreshwaubu ikunzwe cyane mu bitaro. Uruganda rwacu rufite uburyo buhamye bwo kugenzura ubuziranenge bw'ibicuruzwa, kubigeza vuba, no gutanga serivisi yuzuye kandi inoze nyuma yo kugurisha. Abakozi bose baLnkMedtwizeye kwitabira cyane mu nganda za angiography mu gihe kizaza, gukomeza gukora ibikoresho byiza ku bakiriya, no kwita ku barwayi.

Ubushakashatsi bwerekana iki?

Uburyo bushya bwashyizweho muri NCA butuma proton ziruhuka mu gihe kirekire, butuma zikora amashusho meza cyane ku mibare mike cyane ya gadolinium complexes. Imibare mike igabanya ibyago byo kugira ingaruka mbi kuko igipimo cya CA ari gito.

Bitewe n'imiterere yo kwipfunyika, SMDC ivamo ifite igice cy'imbere cyuzuye n'ahantu hahurira abantu benshi. Ibi byongera uburyo bwo kuruhuka kuko ingendo z'imbere n'iz'igice zikikije umurongo wa SMDC-Gd zishobora kugabanywa.

Iyi NCA ishobora kwirundanya mu tumori, bigatuma bishoboka gukoresha uburyo bwo gufata Gd neutron mu kuvura tumori mu buryo bwihariye kandi bunoze. Kugeza ubu, ibi ntibiragerwaho mu buvuzi bitewe no kutagira uburyo bwo guhitamo 157Gd ku tumori no kuzigumana ku rugero rukwiye. Gukenera gutera doze nyinshi bifitanye isano n'ingaruka mbi n'ingaruka mbi kuko ingano nini ya gadolinium ikikije tumori irinda ko tumori yangirika.

Iyi nanoscale ishyigikira ubwiyongere bw'ibipimo byo kuvura no gukwirakwiza neza imiti mu turemangingo. Utunyangingo duto dushobora gusohoka mu mitsi yo mu bwonko, bigatuma habaho imikorere myinshi yo kurwanya tumori.

"Bitewe n’uko umurambararo wa SMDC uri munsi ya nanometero 10, ibyo twabonye bishobora guterwa no kwinjira cyane kwa SMDC mu tumori, bigafasha kwirinda ingaruka zo kurinda za neutron z’ubushyuhe no kwemeza ko elektroni na rayon ya gamma bikwirakwira neza nyuma yo guhura n’ubushyuhe bwa neutron."

Ingaruka ni izihe?

"Ishobora gushyigikira iterambere rya SMDCs nziza kugira ngo isuzuma neza ikibyimba, nubwo byaba ngombwa gutera inshinge nyinshi za MRI."

“Ibyo twabonye bigaragaza ubushobozi bwo kunoza NCA binyuze mu gushushanya molekile ubwayo, kandi bigaragaza iterambere rikomeye mu ikoreshwa rya NCA mu gusuzuma no kuvura kanseri.”