Impinduramatwara Kwikuramo Nanoscale Umukozi wa MRI Utuma Kanseri Yerekana neza

Kwerekana amashusho yubuvuzi akenshi bifasha gupima neza no kuvura imikurire ya kanseri. By'umwihariko, magnetic resonance imaging (MRI) ikoreshwa cyane kubera gukemura cyane, cyane cyane kubintu bitandukanye.

Ubushakashatsi bushya bwasohotse mu kinyamakuru Advanced Science butanga raporo ku kintu gishya cyo kwikuramo nanoscale itandukanye ishobora gufasha kwiyumvisha ibibyimba ku buryo burambuye binyuze kuri MRI.

Ni irihe tandukaniroitangazamakuru?

 Itangazamakuru ritandukanye (rizwi kandi nk'itangazamakuru ritandukanye) ni imiti yatewe (cyangwa yafashwe) mu ngingo z'umuntu cyangwa mu ngingo kugira ngo ishusho yiyongere. Iyi myiteguro iroroshye cyangwa iri munsi yumubiri ukikije, ikora itandukaniro rikoreshwa mukugaragaza amashusho hamwe nibikoresho bimwe. Kurugero, imyiteguro ya iyode, barium sulfate, nibindi bikoreshwa mugukurikirana X-ray. Yatewe mu maraso y’umurwayi binyuze muri siringi itandukanye cyane.

Kuri nanoscale, molekile ziguma mu maraso igihe kirekire kandi zishobora kwinjira mu bibyimba bikomeye bitarinze gutera uburyo bwihariye bwo kwirinda indwara. Ingirabuzimafatizo nyinshi zishingiye kuri nanomolecules zakozweho ubushakashatsi nk'izishobora gutwara CA mu bibyimba.

Ibi bintu bitandukanya nanoscale (NCAs) bigomba gukwirakwizwa neza hagati yamaraso ninyama zinyungu kugirango bigabanye urusaku rwimbere kandi bigere ku kigereranyo kinini cyerekana urusaku (S / N). Iyo yibanze cyane, NCA ikomeza kumaraso mugihe kirekire, bityo bikongera ibyago byo kwandura fibrosis nyinshi bitewe no kurekura ion za gadolinium muri kiriya kigo.

Kubwamahirwe, NCAs nyinshi zikoreshwa zirimo inteko zubwoko butandukanye bwa molekile. Munsi yurugero runaka, izi micelles cyangwa igiteranyo gikunda gutandukana, kandi ibizava muriki gikorwa ntibisobanutse.

Ubu bushakashatsi bwashishikarije kwikuramo nanoscale macromolecules idafite imipaka ikomeye yo gutandukana. Ibi bigizwe nibinure byamavuta hamwe nigishishwa cyo hanze cyanagabanije kugendagenda kwimitwe ya elegitoronike hejuru yubusabane. Ibi birashobora gukurikiraho guhindura ibipimo byo kuruhuka bya molekuline nibindi bikorwa bishobora gukoreshwa mugutezimbere ibiyobyabwenge nibiranga vivo.

Itangazamakuru ritandukanye risanzwe ryinjizwa mumubiri wumurwayi binyuze mumashanyarazi yumuvuduko ukabije.LnkMed, uruganda rwumwuga rwibanda ku bushakashatsi no guteza imbere imiti itandukanye kandi itera inkunga ibikoreshwa, yagurishijeCT, MRI, naDSAinshinge murugo no mumahanga kandi zamenyekanye nisoko mubihugu byinshi. Uruganda rwacu rushobora gutanga inkunga zoseibikoreshwakuri ubu uzwi cyane mubitaro. Uruganda rwacu rufite uburyo bunoze bwo kugenzura ibicuruzwa, gutanga byihuse, na serivisi yuzuye kandi ikora neza nyuma yo kugurisha. Abakozi bose baLnkMedtwizere ko tuzagira uruhare runini mu nganda za angiografiya mu bihe biri imbere, komeza gukora ibicuruzwa byujuje ubuziranenge ku bakiriya, no kwita ku barwayi.

Ubushakashatsi bwerekana iki?

Uburyo bushya bwatangijwe muri NCA butezimbere igihe kirekire cyo kuruhuka kwa proton, ikayemerera gukora amashusho akarishye kurwego rwo hasi rwa gadolinium. Gupakira hasi bigabanya ibyago byingaruka mbi kuko igipimo cya CA ni gito.

Bitewe no kwikuramo imitungo, ibisubizo bya SMDC bifite intangiriro yuzuye hamwe nibidukikije bigoye. Ibi byongera uburuhukiro nkimbere yimbere nu gice gikikije interineti ya SMDC-Gd irashobora kugabanywa.

Iyi NCA irashobora kwirundanyiriza mubibyimba, bigatuma bishoboka gukoresha Gd neutron gufata imiti kugirango ivure ibibyimba byumwihariko kandi neza. Kugeza ubu, ibi ntabwo byagezweho mubuvuzi kubera kubura guhitamo gutanga 157Gd kubyimba no kubikomeza muburyo bukwiye. Gukenera gutera inshuro nyinshi bifitanye isano ningaruka mbi ningaruka mbi kuko ubwinshi bwa gadolinium ikikije ikibyimba irinda neutron.

Nanoscale ishyigikira gukusanya uburyo bwo kuvura no gukwirakwiza imiti mu bibyimba. Molekile ntoya irashobora kuva muri capillaries, bikavamo ibikorwa byinshi birwanya antitumor.

“Urebye ko diameter ya SMDC iri munsi ya 10 nm, ibyo twabonye birashoboka ko bituruka ku kwinjira cyane kwa SMDC mu bibyimba, bigafasha guhunga ingaruka zo gukingira neutron yumuriro no kwemeza ikwirakwizwa rya electron na imirasire ya gamma nyuma yubushyuhe bwa neutron.“

Ingaruka ni izihe?

Ati: "Irashobora gushyigikira iterambere rya SMDCs kugira ngo hasuzumwe neza ibibyimba, kabone n'iyo hakenewe inshinge nyinshi za MRI."

Ati: "Ibyavuye mu bushakashatsi byerekana ubushobozi bwo guhuza neza NCA binyuze mu kwizirika kwa molekuline no kwerekana iterambere rikomeye mu ikoreshwa rya NCA mu gusuzuma no kuvura kanseri."